This book is based upon cutting-edge research conducted in the author’s lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information.
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Biotechnology
Biopharmaceutics
Biotechnology
Reference
Professional

Giving much more attention to noninferiority testing, this second edition provides readers with a rich repertoire of efficient solutions to specific equivalence and noninferiority testing problems frequently encountered in the analysis of real data sets. It also includes new chapters on equivalence tests for multivariate data and tests for relevant differences between treatments. Drawing from real-life medical research, the author uses numerous examples throughout to illustrate the methods. Updated computer programs in SAS, Fortran, and R for facilitating the routine application of testing procedures are available online at www.crcpress.com
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Statistics for the Biological Sciences
Statistical Theory & Methods
Reference
Professional

Building on the success of its popular predecessor, this second edition presents new findings on the species that are important environmental indicators. It covers nearly twice as many topics, including recent developments in the ecotoxicology of amphibians and reptiles, the current status of these animals, and intrinsic factors that affect their susceptibility to contaminants. The book also includes information on specific groups of contaminants and their effects and body burdens in herpetafauna, how contaminants interact with other ecological factors, and concerns for the future.
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Environmental & Ecological Toxicology
Marine & Aquatic Science
Reference
Professional

Considered the definitive work on sex-related homicide, this second edition details the theoretical and psychological basis for sexual homicide and offers practical investigative checklists and directions for processing and interpreting the crime scene. A comprehensive discussion of sexual deviance, it analyzes the typology of offenders to determine their signature aspects. It introduces the latest information on DNA technology, includes a new chapter on the infamous 30-year BTK investigation, offers new research developed from the Working Group of Human Asphyxia (WGHA), and provides a revised chapter on criminal personality profiling and investigative analysis. The new edition contains nearly 400 color photos.
• Practical Aspects of Criminal & Forensic Investigations
Psychological Science
Reference

Based on courses taught by the author for over 15 years, this text raises the scientific awareness of untrained readers. It lays the foundation of the laws that govern our universe in a nontechnical way and outlines the methods developed by physicists for the scientific investigation of nature, contrasting them with those developed by pseudoscience. Noting the damage incurred by confusing science and technology, the book demonstrates that only science is capable of advancing technology. For those desiring deepended understanding, the author provides a healthy dose of technical detail in the accompanying CD.
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General Physics
Textbook

A companion to Volume V: Applications of Ion Trapping Devices , this volume explores the latest advances in this expanding field. It covers new methods for trapping ions, such as the Orbitrap™, the digital ion trap, the rectilinear ion trap, and the toroidal ion trap; the development and application of the quadrupole ion trap and the quadrupole linear ion trap; and the introduction of high-field asymmetric waveform ion mobility spectrometry. The book explains all terms, acronyms, procedures, and equations in a style readily accessible at the graduate level and presents a common writing style that enables readers to appreciate the commonalities of topics.
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Chemical Spectroscopy
Analytical Chemistry
Reference
Professional

Applying quantitative structure-activity relationship (QSAR) techniques at a state-of-the-art level, this book describes how to transform ligand structure-activity relationships into models that predict the potency or activity/inactivity of new molecules. This edition contains a new chapter on methods that identify the 3D conformations to use for 3D QSAR and offers additional discussions on statistical topics, such as partial least squares and kNN potency prediction. Along with re-analyzing old data using newer methods, the expanded case studies explore molecular design based on 3D modeling and include comparisons of ligand- and structure-based models of biological potency.
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Medicinal & Pharmaceutical Chemistry
Physical Chemistry
Chemistry
Reference
Professional

This text provides a solid foundation for the study of advanced mathematics and covers many interesting applications of linear algebra, which show how linear algebra is essential in such diverse areas as combinatorics, differential equations, optimization, and approximation. The book discusses important concepts and methods from numerical linear algebra and contains a range of exercises in each section, including some that can be solved using a computer package such as MATLAB ® . It also incorporates mini-projects that encourage students to develop topics not covered in the text. A forthcoming solutions manual is available for qualifying instructors.
• Discrete Mathematics and Its Applications
Algebra
Computational Physics
Textbook

This text covers the major areas of modern time series models and theory, including time and spectral domain and univariate and multivariate time series methods. It also discusses recent techniques for modeling time series data, such as dynamic graphical models, SMC methods, and nonlinear/non-Gaussian dynamic models. Emphasizing model-based, computationally intensive analysis of structured time series, the authors present analyses of real time series data in numerous examples and case studies to illustrate the flexibility and practical impact of the models and methods. Many of the data sets, R and MATLAB ® code, and other material are available on the authors’ websites.
• Chapman & Hall/CRC Texts in Statistical Science
Statistical Theory & Methods
Statistics
Statistics & Computing
Textbook
Professional

Focusing on practical approaches for the experienced investigator, a 27-year veteran of the FBI presents a hands-on volume drawn from years of experience interviewing suspects. The main focus of the book is the targeted subject interviewing process (TSI). This technique combines all known tactics learned from criminal personality profiling and investigative analysis into an effective strategy for interviewing a suspect. The book describes the skill sets and essential elements that directly contribute to a successful interrogation and outlines an interview plan using these analytical and profiling concepts. Employing crime scene scenarios to demonstrate concepts, the book includes a victim questionnaire capturing offender behavior, form templates, and a glossary.
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Forensic Science - Law
Textbook