In recent years, there has been increased understanding of the mechanisms involved in the transport of metal ions into and out of target cells, particularly epithelial cells. In addition, there have been significant advancements in the roles of certain metal ions in the conformational changes and function of cellular proteins. This volume explains the role of key biologically relevant divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals such as nickel, zinc, and chromium, the text also discusses a few environmentally relevant toxic divalent cations, including mercury, cadmium, and arsenic.
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Cell Biology
Molecular Biology
Toxicology
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Professional

With over 20 easy-to-use template protocols for cleaning validation of extensively used equipments, this book provides technical solutions to assist in fulfilling the training needs of finished pharmaceutical manufacturers. Drawing on the authors’ more than two decades of experience, the text offers hands-on training based on current approaches and techniques. The manual is organized as a database to support those involved in the development, manufacturing, auditing, and validation of bio-pharmaceuticals on a pilot scale, that can lead to scaled-up production. It also provides exclusive training guidelines in a CD-ROM to enable the users to amend or adapt processes as necessary.
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Analysis & Pharmaceutical Quality
Biopharmaceutics
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Many tribological devices act as viable bearings in contrast to basic hydrodynamic theory. Similarly, powder films possess quasi-hydrodynamic features that allow them to act as conventional fluid film bearings. These phenomena have led to a novel definition of lubricants as intermediate layers, detailed in the present volume. Tribology of Interface Layers illustrates that the various lubrication modes, from dry to hydrodynamic to powder lubrication, overlap to such a degree that they exist on a tribological spectrum. Based on experimental and theoretical work, this text shows how the interdependence of powder and hydrodynamic lubrication exemplify this continuum in tribological processes.
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Tribology
Metals & Alloys
Mechanics
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Professional

Focusing on Lean Enterprise, Six Sigma, and Human Systems Dynamics, this guide provides new tools for managing and sustaining process improvement in today’s complex non-linear environments and helps readers apply new, relevant theory to their own management practices. With more than 50 combined years of change management and process improvement consulting experience, the authors offer valuable practical insights for creating dynamic organizational change. They describe the impact of both linear and adaptive approaches to process improvement. Case studies reveal ways to avoid common mistakes and demonstrate how to integrate new processes with past efforts.
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Quality Assurance & Total Quality Management
Quality Control & Reliability
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Highlighting the differences between terrestrial and underwater sensor networks, this book investigates the fundamental aspects of underwater communication. Prominent researchers consider the challenges in the development of underwater acoustic sensor networks (UW-ASNs). They introduce an effective cross-layer approach for effectively integrating communication functionalities as well as a realistic acoustic model characterized by channel utilization efficiency that enables proper setting of the optimal packet size for underwater communications. Discussing architectures for two- and three-dimensional sensor networks, the text covers the wide range of topics relating to UW-ASNs.
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Digital & Wireless Communication
Communications System Design
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Professional

A culmination of the authors’ years of extensive research on the topic, this book provides a complete, self-contained introduction to advances in relational data clustering. It presents a novel theoretical framework as well as the most state-of-the-art models for relational data clustering. The authors also describe a family of new algorithms for various relational clustering problems arising in a wide range of important applications. Concepts and theory are explained through detailed application examples and the book includes a comprehensive reference list of related literature.
• Chapman & Hall/CRC Data Mining and Knowledge Discovery Series
Data Preparation & Mining
Statistics & Computing
Machine Learning
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Professional

This text covers the major areas of modern time series models and theory, including time and spectral domain and univariate and multivariate time series methods. It also discusses recent techniques for modeling time series data, such as dynamic graphical models, SMC methods, and nonlinear/non-Gaussian dynamic models. Emphasizing model-based, computationally intensive analysis of structured time series, the authors present analyses of real time series data in numerous examples and case studies to illustrate the flexibility and practical impact of the models and methods. Many of the data sets, R and MATLAB ® code, and other material are available on the authors’ websites.
• Chapman & Hall/CRC Texts in Statistical Science
Statistical Theory & Methods
Statistics
Statistics & Computing
Textbook
Professional

Emphasizing applications and practical computing aspects, this book presents an up-to-date review of Bayesian hierarchical methods. It provides a complete treatment of the main modeling settings, including meta-analysis, time series, nonlinear regression, and multilevel, multivariate, panel, spatial, and survival data. The text includes realistic worked examples from the social and health sciences, mainly employing the WinBUGS package but also incorporating BayesX code. The author also illustrates MCMC sampling from first principles using R. A set of programs linked to the worked examples is available on www.crcpress.com
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Statistical Theory & Methods
Statistics & Computing
Statistics for the Biological Sciences
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Professional

Edited by renowned protein scientist and bestselling author Roger Lundblad, with the assistance of Fiona Macdonald of CRC Press, this volume represents a dramatic revision — the first in two decades — of one of biochemistry's most referenced works. Presented in a simple-to-use format, this popular reference allows quick access to the most frequently used data on proteins, lipids, nucleic acids, and carbohydrates. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents.
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Biochemistry
Molecular Biology
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Professional

This third edition describes and illustrates more than 515 fungal species, including 49 oomycetous, 35 zygomycetous, 49 ascomycetous, 38 basidiomycetous, and 344 anamorphic species. All fungi are described alphabetically in order of Oomycota, Zygomycota, Ascomycota, Basidiomycota, and Anamorphic (Deuteromycetous) fungi. For each genus, the atlas includes type species, references, morphology, and materials. The book illustrates all fungi alongside morphologies and colonies of their fresh agar cultures or dried specimens, providing ready access to morphologically similar fungi for quick comparison. This edition also contains a bonus CD-ROM, which includes color versions of all images from the book.
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Agriculture
Botany
Microbiology
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